Upcoming ABC Webinar: "The Use of High Resolution Accurate Mass Spectrometry in Environmental Fate and Metabolism Studies"

The use of liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS) can be a powerful tool in the characterization and identification of metabolites and degradation products of environmental pollutants in environmental fate and metabolism studies, whether conducted in the laboratory or the field. Advantages of HRMS include:

• Improved accuracy – important in distinguishing analytes from isobaric interferences in complicated matrices

• Improved post-acquisition data processing – important in reducing the number of analyses and experiments required to get results

• Scientific and regulatory necessity – important owing to the required non-targeted analysis of novel compounds dosed at ever lower levels

This webinar will review the merits of employing LC-HRMS by addressing these basic concepts:

• Scientific and regulatory importance of metabolite identification

• Instrument Platforms

• Mass resolution and accurate mass measurements

• Molecular Formula Information (Most Probable Elemental Composition)

• Data-Processing Techniques (mass defect filtering, isotope pattern, etc.)

• The Importance of Separations Chemistry

• Future Developments of HRMS in Environmental Fate and Metabolism

The presentation will also review case studies in the scientific literature and examples from our laboratory to illustrate how HRMS can be employed in environmental fate and metabolism studies to answer both scientific and regulatory questions.